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Side effects limit long-term use and truly impairquality of life. Even thoughchronic osteomyelitis is generally of infectious origin, rare immunological inflammatorydisorders of the bone, such as SAPHO (synovitis, acne, pustulosis, hyperostosis, and osteitis)syndrome or recurrent multifocal osteomyelitis, do exist [2–4]

Even thoughchronic osteomyelitis is generally of infectious origin, rare immunological inflammatorydisorders of the bone, such as SAPHO (synovitis, acne, pustulosis, hyperostosis, and osteitis)syndrome or recurrent multifocal osteomyelitis, do exist [2–4].

Suppose, for example, that the pairs were assembled by selecting subjects fromtwo different clinical settings and matching one member from each setting to one memberof the other setting. p53 can triggerapoptosis in hypoxia by directly up-regulating Bnip3L, without affecting other tar-get genes, such as Puma, Bax and DR5 [ 13]

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Shvarts A et al (1996) MDMX: a novel p53-binding protein with some functional propertiesof MDM2.

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